The national PRINCIPLE trial is looking to find low-risk treatments that can be taken at home for people with COVID-19 symptoms.

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  • men and women aged 65+, OR
  • men and women aged 18-64 and experiencing shortness of breath as part of COVID-19 illness, with symptoms within the past 14 days
  • men and women aged 18-64 with underlying health conditions, with symptoms within the past 14 days


  • You will either receive usual care, or usual care and a study drug which will be delivered from your GP, or directly from the research team.
  • All study drugs are already widely used in the NHS and have been approved as safe for use in this study.
  • The study will use a computer programme to decide by chance whether you get the drug or not.

Recruiting until

  • 31 October 2022

Trial ID

  • ISRCTN86534580