This study will investigate the links between the immune system and cognitive decline after stroke. It is looking for people who have not had a stroke to act as ‘control participants’.

Results of this study will be used to inform the development of targeted treatments and improved recovery for people who have a stroke in the future.

The Stroke-Immune Pathways and Cognitive Trajectory (Stroke IMPaCT) study is funded by the Leducq Foundation. It is being carried out by a team of researchers led by Professor Craig Smith at Salford Royal in collaboration with The University of Manchester and Stanford University.


  • Healthy volunteers
  • Aged 45+
  • No previous stroke, brain haemorrhage, brain injury or neurological disorder (eg multiple sclerosis)
  • Not taking immunomodulating or immunosuppressant medicines.


  • Salford Royal Hospital (part of the Northern Care Alliance)


Taking part will involve one of the following:

Option one
Attending up to three appointments (approx 30 minutes each) where you will be asked to provide basic medical, health and demographic information as well as donating a sample of blood.

Option two
As above with additional assessment of cognitive function and mobility. Following this, you will be invited to attend a brain scan (approx 1 hour).

Participants will be provided with transport or compensated for travel costs. Those selected to undergo a brain scan will receive a payment of £30.

Recruiting until

  • 31 December 2024

Want to take part or learn more?