The CICERO study is investigating cognitive impairment in people experiencing symptoms of long Covid (cognitive Covid).

Cognitive impairment (sometimes known as ‘brain fog’) is recognised as one of the major symptoms of long Covid and is estimated to affect up to 75% of people.

CICERO (Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn) is exploring the relationships between cognitive impairment and other symptoms of long Covid including, fatigue, anxiety, depression, and sleep disturbance

Findings from this study will be used to understand if neuropsychological rehabilitation can help people with cognitive Covid return to normal brain function.

This study is being carried out by a team of researchers at Greater Manchester Mental Health NHS Foundation Trust on behalf of the UCL Institute of Cognitive Neuroscience.


  • Age 30-60
  • Previous Covid infection or symptoms of long Covid
  • Cognitive impairment that has lasted for more than three months after Covid infection


Manchester Royal Infirmary


Taking part involves:

  • Completing a series of online questionnaires about your health including information Covid vaccination, infection and symptoms as well as some demographic information (approx. 30 minutes)
  • Attending one clinic appointment at Manchester Royal Infirmary (approx. 2 hours, including breaks), which will include several cognitive assessments measuring memory, attention, thinking speed and brain function.
  • Completing three further memory assessments using a smartphone app (approx. 2 hours)

People completing part one of the study may be invited to take part in a further stage of this research.

Participants will receive travel expenses up to £20 for each clinic appointment.

Recruiting until

  • 31 January 2024

Want to take part or learn more?

Share this study