Elderly man in a hat smiling.

CHIEF-PD trial

The CHIEF-PD trial is looking to determine if a certain medication can help prevent falls in people with Parkinson’s Disease.

Falls are a common complication of Parkinson’s and can lead to injuries and reduced confidence when walking.  Previous trials have highlighted that drugs called cholinesterase inhibitors, used to treat dementia and memory problems, can help make walking steadier and therefore reduce the number of falls people experience.

This study is being carried out by researchers from the University of Bristol and is funded by Royal United Hospitals Bath NHS Foundation Trust.


  • Have a diagnosis of Parkinson’s disease
  • Had at least one fall in the last 12-months
  • Able to walk a minimum of 10 meters without an aid.


  • Salford Royal (Clinical Research Facility) M6 8HD


  • Fairfield General Hospital (Clinical Research Facility) BL9 7TD


  • Attend two clinic visits (12 months apart). Each will include a physical examination, recording of blood pressure, walking tests and completion of a health questionnaire.
  • Use a new medication (via a patch applied to your skin) for a 12-month period *
  • Keep a monthly diary of medication used
  • Receive monthly telephone calls to monitor progress and record details of any falls you may have had

* Participants will be randomly selected to receive either the new drug or a placebo.

Recruiting until

  • 30 April 2023

Trial ID

  • NCT04226248

Want to take part or learn more?